HELPING THE OTHERS REALIZE THE ADVANTAGES OF INDAZOLE NMR

Helping The others Realize The Advantages Of indazole nmr

Helping The others Realize The Advantages Of indazole nmr

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Substrates 1b–d bearing methoxy and benzyloxy groups offered indazoles 4e–g in an excellent to reasonable yield. In the case of substrates 1e,f bearing electron-withdrawing substituents, yields of products 4h, i were decreased.

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-positions, was observed and 3h and 3i were obtained in sixty seven% and fifty eight% yields, respectively. Moreover, the aromatic aldehyde that contains an electron-withdrawing group (EWG) 2p was identified to generally be entirely unwilling to endure the optimized response problems. In the same way, phenyl acetaldehyde 2q was also observed to become unreactive. On top of that, to be able to Look at the versatility on the methodology, a handful of aliphatic aldehydes 2j–k have been reacted with 1a beneath the optimized response situations and afforded 3j and 3k in 68% and sixty one% yields, respectively.

, OCH3) groups was subjected to reaction with 1a beneath the optimized problems; 3d was afforded in marginally lessen (seventy eight%) produce in comparison to 3a and 3c. This might be due to steric hindrance produced through the OCH3 group at the o

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